ENHANCED PROAPOPTOTIC EFFECTS OF WATER DISPERSED COMPLEXES OF 4-THIAZOLIDINONE-BASED CHEMOTHERAPEUTICS WITH A PEG-CONTAINING POLYMERIC NANOCARRIER

Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

Abstract Aim To study whether water formulation of the complex of 4-thiazolidinone derivatives with a PEG-containing polymeric nanocarrier enhances their pro-apoptotic action towards rat glioma C6 cells.Methods Mechanisms of antineoplastic effects of 4-thiazolidinone derivatives were investigated in vitro with rat glioma C6 cells.Cell nativity, cel

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Killing Time. Ennui in Eighteenth-Century English Culture

The article explores the meanings of ennui in eighteenth-century England.Based on text searches, Oil Filter it proposes that the French term ennui was adopted into everyday usage in England around the mid-century, and was from the 1770s onwards used to signify especially the temporal aspects of the word, that is, boredom.Ennui was closely tied to s

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The feasibility of assessing frailty and sarcopenia in hospitalised older people: a comparison of commonly used tools

Abstract Background Frailty and sarcopenia are common amongst hospitalised older people and associated with poor healthcare outcomes.Widely recognised tools for their identification are the Fried Frailty Phenotype, its self-report version the FRAIL Scale, and the European Working Group on Sarcopenia in Older People (EWGSOP) criteria.We studied the

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